Professor Bradley completed his Ph.D. studies in genetics at the University of Cambridge in 1984. During his time in Cambridge Dr. Bradley co-developed the embryonic stem cell system. Embryonic stem cells can be isolated from mouse embryos, grown & genetically manipulated in culture and then used to re-create mice with these mutations.
In 1987, Dr. Bradley moved to Baylor College of Medicine, Houston, Texas as an Assistant Professor and was promoted to full Professor in 1995. In 1993 Dr. Bradley received a prestigious appointment as an Investigator with the Howard Hughes Medical Institute. At Baylor, Dr. Bradley’s laboratory pursued the analysis of gene function using knockout mice and has published the function of numerous genes using this technology, with an emphasis on tumour suppression and embryonic development. Dr. Bradley’s laboratory has also developed novel methods to engineer the genomes of mice, including point mutations and large chromosomal changes. Dr. Bradley is the author of over 200 scientific articles and book chapters.
He has been active in commercialising technology from his laboratory by founding several companies including a publicly traded genomics company, Lexicon Genetics Inc. In November 2000, Dr. Bradley took up an appointment as Director of the Sanger Centre. In July 2002 he was elected Fellow of the Royal Society.
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